The Casa de Mateus was built in the first half of the 18th Century by António José Botelho Mourão (1688-1746), 3rd Morgado of Mateus. The chapel was finished by his son, D. Luís António de Sousa Botelho Mourão (1722-1798).

The architectural design of the house, ex-libris of the Portuguese baroque, is attributed to the great Italian architect Nicolau Nasoni and manages to harmonize the traditionally comfortable dimensions of the Portuguese noble house to the baroque exhuberance displayed in the main façade, the decorative motifs of the roofs and in the chapel designed by Master José Álvares do Rego.